A generalized model to estimate the statistical power in mitochondrial disease studies involving 2×k tables.

ABSTRACT:

Background

Mitochondrial DNA (mtDNA) variation (i.e. haplogroups) has been analyzed in regards to a number of multifactorial diseases. The statistical power of a case-control study determines the a priori probability to reject the null hypothesis of homogeneity between cases and controls.

Methods/principal findings

We critically review previous approaches to the estimation of the statistical power based on the restricted scenario where the number of cases equals the number of controls, and propose a methodology that broadens procedures to more general situations. We developed statistical procedures that consider different disease scenarios, variable sample sizes in cases and controls, and variable number of haplogroups and effect sizes. The results indicate that the statisti

SUBMITTER: Pardo-Seco J 

PROVIDER: S-EPMC3785462 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature