Repeated ketamine exposure induces an enduring resilient phenotype in adolescent and adult rats.

ABSTRACT:

Background

Major depressive disorder afflicts up to 10% of adolescents. However, nearly 50% of those afflicted are considered nonresponsive to available treatments. Ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist has shown potential as a rapid-acting and long-lasting treatment for major depressive disorder in adults. Thus, the effectiveness and functional consequences of ketamine exposure during adolescence were explored.

Methods

Adolescent male rats (postnatal day [PD] 35) received two ketamine (0, 5, 10, or 20 mg/kg) injections, 4 hours apart, after exposure to day 1 of the forced swim test (FST). The next day, rats were reexposed to the FST to assess ketamine-induced antidepressant-like responses. Separate groups were exposed to chronic unpredictable s

SUBMITTER: Parise EM 

PROVIDER: S-EPMC3785550 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature