Aging-associated exacerbation in fatty degeneration and infiltration after rotator cuff tear.

ABSTRACT:

Background

Rotator cuff tears are one of the most common musculoskeletal complaints and a substantial source of morbidity in elderly patients. Chronic cuff tears are associated with muscle atrophy and an infiltration of fat to the area, a condition known as "fatty degeneration." To improve the treatment of cuff tears in elderly patients, a greater understanding of the changes in the contractile properties of muscle fibers and the molecular regulation of fatty degeneration is essential.

Methods

Using a full-thickness, massive supraspinatus and infraspinatus tear model in elderly rats, we measured fiber contractility and determined changes in fiber type distribution that develop 30 days after tear. We also measured the expression of messenger RNA and micro-RNA transcripts invo

SUBMITTER: Gumucio JP 

PROVIDER: S-EPMC3785561 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature