Effect of amniotic fluid stem cells and amniotic fluid cells on the wound healing process in a white rat model.

ABSTRACT:

Background

Amniotic-fluid-derived stem cells and amniocytes have recently been determined to have wound healing effects, but their mechanism is not yet clearly understood. In this study, the effects of amniotic fluid stem cells and amniocytes on wound healing were investigated through animal experiments.

Methods

On the back of Sprague-Dawley rats, four circular full-thickness skin wounds 2 cm in diameter were created. The wounds were classified into the following four types: a control group using Tegaderm disc wound dressings and experimental groups using collagen discs, amniotic fluid stem cell discs, and amniocyte discs. The wounds were assessed through macroscopic histological examination and immunohistochemistry over a period of time.

Results

The amniotic fluid st

SUBMITTER: Yang JD 

PROVIDER: S-EPMC3785580 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature