Portfolios of biomedical HIV interventions in South Africa: a cost-effectiveness analysis.

ABSTRACT:

Background

Recent clinical trials of male circumcision, oral pre-exposure prophylaxis (PrEP), and a vaginal microbicide gel have shown partial effectiveness at reducing HIV transmission, stimulating interest in implementing portfolios of biomedical prevention programs.

Objective

To evaluate the effectiveness and cost-effectiveness of combination biomedical HIV prevention and treatment scale-up in South Africa, given uncertainty in program effectiveness.

Design

Dynamic HIV transmission and disease progression model with Monte Carlo simulation and cost-effectiveness analysis.

Participants

Men and women aged 15 to 49 years in South Africa.

Interventions

HIV screening and counseling, antiretroviral therapy (ART), male circumcision, PrEP, microbicide, and sel

SUBMITTER: Long EF 

PROVIDER: S-EPMC3785647 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature