Lack of Association between the MEF2A Gene and Coronary Artery Disease in Iranian Families.

ABSTRACT:

Objective(s)

Coronary artery disease (CAD) which may lead to myocardial infarction (MI) is a complex one. Great effort has been devoted to identification of genes that increase susceptibility to CAD or provide protection. A 21-bp deletion in the MEF2A gene, which encodes a member of the myocyte enhancer factor 2 family of transcription factors, has been reported in patients of a single pedigree that exhibited autosomal-dominant inheritance of CAD. Subsequent analysis of genetic variants within the gene in CAD and MI case-control settings produced inconsistent results. Here, we aimed at assessing the contribution of MEF2A to CAD in a cohort of Iranian CAD patients.

Materials and methods

Exon 11 of MEF2A wherein the above mentioned 21-bp deletion and a polyglutamine (CAG)n pol

SUBMITTER: Inanloo Rahatloo K 

PROVIDER: S-EPMC3786110 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature