Complex temporal changes in TGFβ oncogenic signaling drive thyroid carcinogenesis in a mouse model.

ABSTRACT: Despite recent advances, understanding of molecular genetic alterations underlying thyroid carcinogenesis remains unclear. One key question is how dynamic temporal changes in global genomic expression affect carcinogenesis as the disease progresses. To address this question, we used a mouse model that spontaneously develops follicular thyroid cancer similar to human cancer (Thrb (PV/PV) mice). Using complementary DNA microarrays, we compared global gene expression profiles of thyroid tumors of Thrb (PV/PV) mice with the age- and gender-matched thyroids of wild-type mice at 3 weeks and at 2, 4, 6 and 14 months. These time points covered the pathological progression from early hyperplasia to capsular invasion, vascular invasion and eventual metastasis. Microarray data indicated that 462 gene

SUBMITTER: Kim DW 

PROVIDER: S-EPMC3786374 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature