Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients.

ABSTRACT:

Background

Diagnosing obstructive coronary artery disease (CAD) in at-risk patients can be challenging and typically requires both noninvasive imaging methods and coronary angiography, the gold standard. Previous studies have suggested that peripheral blood gene expression can indicate the presence of CAD.

Objective

To validate a previously developed 23-gene, expression-based classification test for diagnosis of obstructive CAD in nondiabetic patients.

Design

Multicenter prospective trial with blood samples obtained before coronary angiography. (ClinicalTrials.gov registration number: NCT00500617) SETTING: 39 centers in the United States.

Patients

An independent validation cohort of 526 nondiabetic patients with a clinical indication for coronary angiography.

SUBMITTER: Rosenberg S 

PROVIDER: S-EPMC3786733 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature