An updated meta-analysis on the association of MDM2 SNP309 polymorphism with colorectal cancer risk.

ABSTRACT:

Background

The mouse double minute 2 (MDM2) gene encodes a phosphoprotein that interacts with P53 and negatively regulates its activity. The SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and tumor development. Studies investigating the association between MDM2 SNP309 polymorphism and colorectal cancer (CRC) risk reported conflicting results. We performed a meta-analysis of all available studies to explore the association of this polymorphism with CRC risk.

Methods

All studies published up to July 2013 on the association between MDM2 SNP309 polymorphism and CRC risk were identified by searching electronic databases PubMed, EMBASE, and Chinese Biomedical Literature database (CBM) databases. The associati

SUBMITTER: Qin X 

PROVIDER: S-EPMC3786895 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature