Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.

ABSTRACT:

Introduction

Recent studies have shown that histones, the chief protein component of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and act as major mediators of the death of an organism. This study was designed to elucidate the cellular and molecular basis of histone-induced lethality and to assess the protective effects of recombinant thrombomodulin (rTM). rTM has been approved for the treatment of disseminated intravascular coagulation (DIC) in Japan, and is currently undergoing a phase III clinical trial in the United States.

Methods

Histone H3 levels in plasma of healthy volunteers and patients with sepsis and DIC were measured using enzyme-linked immunosorbent assay. Male C57BL/6 mice were injected intraveno

SUBMITTER: Nakahara M 

PROVIDER: S-EPMC3786915 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature