Loss of fibrinogen in zebrafish results in symptoms consistent with human hypofibrinogenemia.

ABSTRACT: Cessation of bleeding after trauma is a necessary evolutionary vertebrate adaption for survival. One of the major pathways regulating response to hemorrhage is the coagulation cascade, which ends with the cleavage of fibrinogen to form a stable clot. Patients with low or absent fibrinogen are at risk for bleeding. While much detailed information is known about fibrinogen regulation and function through studies of humans and mammalian models, bleeding risk in patients cannot always be accurately predicted purely based on fibrinogen levels, suggesting an influence of modifying factors and a need for additional genetic models. The zebrafish has orthologs to the three components of fibrinogen (fga, fgb, and fgg), but it hasn't yet been shown that zebrafish fibrinogen functions to prevent bleed

SUBMITTER: Vo AH 

PROVIDER: S-EPMC3787019 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature