Decreased expression of nuclear p300 is associated with disease progression and worse prognosis of melanoma patients.

ABSTRACT:

Background

Genomic instability due to UV radiation is one of the leading causes for melanoma. Histone acetyltransferase p300 plays an indispensible role in DNA repair and maintenance of genomic integrity. The present study was performed to analyze the correlation between p300 expression, melanoma progression and patient survival.

Methods

Tissue microarray and immunohistochemical analysis was employed to study the expression of p300 in melanoma patients. A total of 358 melanoma patients (250 primary melanoma and 108 metastatic melanoma) were used for the study. Kaplan-Meier, univariate and multivariate Cox regression analysis, and receiver-operating characteristic curves, were used to elucidate the prognostic significance of p300 expression.

Results

Our results demonst

SUBMITTER: Rotte A 

PROVIDER: S-EPMC3787094 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature