Effect of ω-3 fatty acid supplementation on endothelial function, endogenous fibrinolysis and platelet activation in patients with a previous myocardial infarction: a randomised controlled trial.

ABSTRACT:

Objective

The mechanisms through which ω-3 fatty acids reduce adverse cardiac events remain uncertain. We aimed to investigate the effect of ω-3 fatty acid supplementation on endothelial vasomotor function, endogenous fibrinolysis, and platelet and monocyte activation in patients with coronary heart disease.

Design

Randomised, double-blind, placebo-controlled, cross-over trial.

Setting

Academic cardiac centre.

Participants

20 male patients with a previous myocardial infarction.

Intervention

ω-3 Fatty acid supplementation (2 g/day for 6 weeks) versus olive oil placebo.

Outcome measures

Peripheral blood was taken for analysis of platelet and monocyte activation, and forearm blood flow (FBF) was assessed in a subset of 12 patients during intrabrachia

SUBMITTER: Din JN 

PROVIDER: S-EPMC3787492 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature