Antidepressant response in patients with major depression exposed to NSAIDs: a pharmacovigilance study.

ABSTRACT: OBJECTIVE It has been suggested that there is a mechanism by which nonsteroidal anti-inflammatory drugs (NSAIDs) may interfere with antidepressant response, and poorer outcomes among NSAID-treated patients were reported in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. To attempt to confirm this association in an independent population-based treatment cohort and explore potential confounding variables, the authors examined use of NSAIDs and related medications among 1,528 outpatients in a New England health care system. METHOD Treatment outcomes were classified using a validated machine learning tool applied to electronic medical records. Logistic regression was used to examine the association between medication exposure and treatment outcomes, adjusted for pote

SUBMITTER: Gallagher PJ 

PROVIDER: S-EPMC3787520 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature