NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.

ABSTRACT: Nuclear distribution element 1 (NDE1, also known as NudE) and NDE-like 1 (NDEL1, also known as Nudel) are paralogous proteins essential for mitosis and neurodevelopment that have been implicated in psychiatric and neurodevelopmental disorders. The two proteins possess high sequence similarity and have been shown to physically interact with one another. Numerous lines of experimental evidence in vivo and in cell culture have demonstrated that these proteins share common functions, although instances of differing functions between the two have recently emerged. We review the key aspects of NDE1 and NDEL1 in terms of recent advances in structure elucidation and cellular function, with an emphasis on their differing mechanisms of post-translational modification. Based on a review of the litera

SUBMITTER: Bradshaw NJ 

PROVIDER: S-EPMC3787581 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature