Eph/Ephrin signalling maintains eye field segregation from adjacent neural plate territories during forebrain morphogenesis.

ABSTRACT: During forebrain morphogenesis, there is extensive reorganisation of the cells destined to form the eyes, telencephalon and diencephalon. Little is known about the molecular mechanisms that regulate region-specific behaviours and that maintain the coherence of cell populations undergoing specific morphogenetic processes. In this study, we show that the activity of the Eph/Ephrin signalling pathway maintains segregation between the prospective eyes and adjacent regions of the anterior neural plate during the early stages of forebrain morphogenesis in zebrafish. Several Ephrins and Ephs are expressed in complementary domains in the prospective forebrain and combinatorial abrogation of their activity results in incomplete segregation of the eyes and telencephalon and in defective evagination

SUBMITTER: Cavodeassi F 

PROVIDER: S-EPMC3787759 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature