Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer.

ABSTRACT:

Background and purpose

Rectal bleeding can occur following radiotherapy for prostate cancer and negatively impacts quality of life for cancer survivors. Treatment and clinical factors do not fully predict rectal bleeding, and genetic factors may be important.

Materials and methods

A genome-wide association study (GWAS) was performed to identify SNPs associated with the development of late rectal bleeding following radiotherapy for prostate cancer. Logistic regression was used to test the association between 614,453 SNPs and rectal bleeding in a discovery cohort (79 cases, 289 controls), and top-ranking SNPs were tested in a replication cohort (108 cases, 673 controls) from four independent sites.

Results

rs7120482 and rs17630638, which tag a single locus on chromosome

SUBMITTER: Kerns SL 

PROVIDER: S-EPMC3787843 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature