Environmental tobacco smoke and airway obstruction in children with sickle cell anemia.

ABSTRACT:

Background

The contribution of environmental tobacco smoke (ETS) exposure to pulmonary morbidity in children with sickle cell anemia (SCA) is poorly understood. We tested the hypothesis that children with SCA and ETS exposure would have an increased prevalence of obstructive lung disease and respiratory symptoms compared with children with SCA and no ETS exposure.

Methods

Parent reports of ETS and respiratory symptom frequency were obtained for 245 children with SCA as part of a multicenter prospective cohort study. One hundred ninety-six children completed pulmonary function testing. Multivariable regression models were used to evaluate the associations between ETS exposure at different time points (prenatal, infant [birth to 2 years], preschool [2 years to first grade], an

SUBMITTER: Cohen RT 

PROVIDER: S-EPMC3787918 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature