The QT interval and risk of incident atrial fibrillation.

ABSTRACT:

Background

Abnormal atrial repolarization is important in the development of atrial fibrillation (AF), but no direct measurement is available in clinical medicine.

Objective

To determine whether the QT interval, a marker of ventricular repolarization, could be used to predict incident AF.

Methods

We examined a prolonged QT interval corrected by using the Framingham formula (QT(Fram)) as a predictor of incident AF in the Atherosclerosis Risk in Communities (ARIC) study. The Cardiovascular Health Study (CHS) and Health, Aging, and Body Composition (ABC) study were used for validation. Secondary predictors included QT duration as a continuous variable, a short QT interval, and QT intervals corrected by using other formulas.

Results

Among 14,538 ARIC study particip

SUBMITTER: Mandyam MC 

PROVIDER: S-EPMC3787974 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature