Growth-inhibitory activity of natural and synthetic isothiocyanates against representative human microbial pathogens.

ABSTRACT:

Aims

The aim of this study was to test the growth inhibition activity of isothiocyanates (ITCs), defence compounds of plants, against common human microbial pathogens.

Methods and results

In this study, we have tested the growth-inhibitory activity of a diverse collection of new and previously known representative ITCs of various structural classes against pathogenic bacteria, fungi and moulds by a serial dilution method. Generally, the compounds were more active against Gram-positive bacteria and fungi exhibiting species-specific bacteriostatic or bactericidal effect. The most active compounds inhibited the growth of both drug-susceptible and multi-drug-resistant (MDR) pathogens at micromolar concentrations. In the case of Mycobacterium tuberculosis, some compounds were mor

SUBMITTER: Kurepina N 

PROVIDER: S-EPMC3787980 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature