Low levels of a natural IgM antibody are associated with vein graft stenosis and failure.

ABSTRACT:

Background

All humans have natural, protective antibodies directed against phosphorylcholine (PC) epitopes, a common inflammatory danger signal appearing at sites of cell injury, oxidative stress, and on bacterial capsules. In large human cohorts, low levels of anti-PC IgM were associated with a significantly increased risk of stroke or myocardial infarction. However, it is not known if these antibodies protect against the premature closure of arterial reconstructions.

Methods

A prospective, observational study of patients undergoing elective, infrainguinal, autogenous vein bypasses for atherosclerotic occlusive disease of the legs was conducted. Clinical data were recorded prospectively, and preoperative levels of anti-PC IgM measured with the CVDefine kit from Athera Biote

SUBMITTER: Sobel M 

PROVIDER: S-EPMC3788066 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature