Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.

ABSTRACT: Ca(2+)/calmodulin dependent protein kinase II (CaMKII) is a broadly distributed metazoan Ser/Thr protein kinase that is important in neuronal and cardiac signaling. CaMKII forms oligomeric assemblies, typically dodecameric, in which the calcium-responsive kinase domains are organized around a central hub. We review the results of crystallographic analyses of CaMKII, including the recently determined structure of a full-length and autoinhibited form of the holoenzyme. These structures, when combined with other data, allow informed speculation about how CaMKII escapes calcium-dependence when calcium spikes exceed threshold frequencies.

SUBMITTER: Stratton MM 

PROVIDER: S-EPMC3788167 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature