Toward breaking the histone code: bayesian graphical models for histone modifications.

ABSTRACT:

Background

Histones are proteins that wrap DNA around in small spherical structures called nucleosomes. Histone modifications (HMs) refer to the post-translational modifications to the histone tails. At a particular genomic locus, each of these HMs can either be present or absent, and the combinatory patterns of the presence or absence of multiple HMs, or the histone codes, are believed to coregulate important biological processes. We aim to use raw data on HM markers at different genomic loci to (1) decode the complex biological network of HMs in a single region, and (2) demonstrate how the HM networks differ in different regulatory regions. We suggest that these differences in network attributes form a significant link between histones and genomic functions.

Methods and result

SUBMITTER: Mitra R 

PROVIDER: S-EPMC3788610 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature