The mutational landscape of phosphorylation signaling in cancer.

ABSTRACT: Somatic mutations in cancer genomes include drivers that provide selective advantages to tumor cells and passengers present due to genome instability. Discovery of pan-cancer drivers will help characterize biological systems important in multiple cancers and lead to development of better therapies. Driver genes are most often identified by their recurrent mutations across tumor samples. However, some mutations are more important for protein function than others. Thus considering the location of mutations with respect to functional protein sites can predict their mechanisms of action and improve the sensitivity of driver gene detection. Protein phosphorylation is a post-translational modification central to cancer biology and treatment, and frequently altered by driver mutations. Here we us

SUBMITTER: Reimand J 

PROVIDER: S-EPMC3788619 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature