Comparative efficacy and acceptability of antidepressants in Parkinson's disease: a network meta-analysis.

ABSTRACT:

Background

Depression is a common non-motor symptom in patients with Parkinson's disease (PD). There are many kinds of antidepressants being used, such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and Dopamine agonists which are suggested as alternative antidepressants for the treatment of depression in PD. Which one should we choose first? Literatures have shown inconsistent results.

Methods

We conducted a network meta-analysis of randomized controlled trials to compare the efficacy and acceptability of therapeutic methods for the treatment of depression in Parkinson's disease.

Results

We used the odds ratios (OR) as effect size firstly and the results indicated no stat

SUBMITTER: Liu J 

PROVIDER: S-EPMC3788746 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature