Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization.

ABSTRACT:

Background

Tau protein is implicated in the pathogenesis of neurodegenerative disorders such as tauopathies including Alzheimer disease, and Tau fibrillization is thought to be related to neuronal toxicity. Physiological inhibitors of Tau fibrillization hold promise for developing new strategies for treatment of Alzheimer disease. Because protein disulfide isomerase (PDI) is both an enzyme and a chaperone, and implicated in neuroprotection against Alzheimer disease, we want to know whether PDI can prevent Tau fibrillization. In this study, we have investigated the interaction between PDI and Tau protein and the effect of PDI on Tau fibrillization.

Methodology/principal findings

As evidenced by co-immunoprecipitation and confocal laser scanning microscopy, human PDI interacts

SUBMITTER: Xu LR 

PROVIDER: S-EPMC3788760 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature