Plasma lipidomic profile signature of hypertension in Mexican American families: specific role of diacylglycerols.

ABSTRACT: Both as a component of metabolic syndrome and as an independent entity, hypertension poses a continued challenge with regard to its diagnosis, pathogenesis, and treatment. Previous studies have documented connections between hypertension and indicators of lipid metabolism. Novel technologies, such as plasma lipidomic profiling, promise a better understanding of disorders in which there is a derangement of the lipid metabolism. However, association of plasma lipidomic profiles with hypertension in a high-risk population, such as Mexican Americans, has not been evaluated before. Using the rich data and sample resource from the ongoing San Antonio Family Heart Study, we conducted plasma lipidomic profiling by combining high-performance liquid chromatography with tandem mass spectroscopy to ch

SUBMITTER: Kulkarni H 

PROVIDER: S-EPMC3789127 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature