Renal survival in proteinase 3 and myeloperoxidase ANCA-associated systemic vasculitis.

ABSTRACT:

Background and objectives

This study evaluated predictors for patient and renal survival in patients with ANCA-associated vasculitis (AAV) with and without renal involvement.

Design, setting, participants, & measurements

There were 273 consecutive AAV patients from January 1990 until December 2007 who were followed until death, loss to follow-up, or December 2010. Based on organ involvement, patients were divided into renal (n=212) and nonrenal groups (n=61). The primary end point was ESRD requiring renal replacement therapy (RRT) or renal transplantation or death.

Results

Patient survival was significantly better in the nonrenal group compared with the renal group (hazard ratio, 0.55; 95% confidence interval, 0.33 to 0.92; P=0.02). In the renal group, renal survival

SUBMITTER: de Joode AA 

PROVIDER: S-EPMC3789333 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature