ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure.

ABSTRACT:

Context

The genetic contribution to liability for opioid dependence is well established; identification of the responsible genes has proved challenging.

Objective

To examine association of 1430 candidate gene single-nucleotide polymorphisms (SNPs) with heroin dependence, reporting here only the 71 SNPs in the chromosome 11 gene cluster (NCAM1, TTC12, ANKK1, DRD2) that include the strongest observed associations.

Design

Case-control genetic association study that included 2 control groups (lacking an established optimal control group).

Setting

Semistructured psychiatric interviews.

Participants

A total of 1459 Australian cases ascertained from opioid replacement therapy clinics, 531 neighborhood controls ascertained from economically disadvantaged areas n

SUBMITTER: Nelson EC 

PROVIDER: S-EPMC3789525 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature