Blood pressure lowering and major cardiovascular events in people with and without chronic kidney disease: meta-analysis of randomised controlled trials.

ABSTRACT:

Objective

To define the cardiovascular effects of lowering blood pressure in people with chronic kidney disease.

Design

Collaborative prospective meta-analysis of randomised trials.

Data sources and eligibility

Participating randomised trials of drugs to lower blood pressure compared with placebo or each other or that compare different blood pressure targets, with at least 1000 patient years of follow-up per arm.

Main outcome measures

Major cardiovascular events (stroke, myocardial infarction, heart failure, or cardiovascular death) in composite and individually and all cause death.

Participants

26 trials (152,290 participants), including 30,295 individuals with reduced estimated glomerular filtration rate (eGFR), which was defined as eGFR <60 mL/min/1.7

SUBMITTER: Blood Pressure Lowering Treatment Trialists' Collaboration 

PROVIDER: S-EPMC3789583 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature