Salmonella modulation of host cell gene expression promotes its intracellular growth.
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ABSTRACT:
SUBMITTER: Hannemann S
PROVIDER: S-EPMC3789771 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Salmonella modulation of host cell gene expression promotes its intracellular growth.
Hannemann Sebastian S Gao Beile B Galán Jorge E JE
PLoS pathogens 20131003 10
Salmonella Typhimurium has evolved a complex functional interface with its host cell largely determined by two type III secretion systems (T3SS), which through the delivery of bacterial effector proteins modulate a variety of cellular processes. We show here that Salmonella Typhimurium infection of epithelial cells results in a profound transcriptional reprogramming that changes over time. This response is triggered by Salmonella T3SS effector proteins, which stimulate unique signal transduction ...[more]
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