Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube.

ABSTRACT: Pattern formation in developing tissues is driven by the interaction of extrinsic signals with intrinsic transcriptional networks that together establish spatially and temporally restricted profiles of gene expression. How this process is orchestrated at the molecular level by genomic cis-regulatory modules is one of the central questions in developmental biology. Here we have addressed this by analysing the regulation of Pax3 expression in the context of the developing spinal cord. Pax3 is induced early during neural development in progenitors of the dorsal spinal cord and is maintained as pattern is subsequently elaborated, resulting in the segregation of the tissue into dorsal and ventral subdivisions. We used a combination of comparative genomics and transgenic assays to define and dis

SUBMITTER: Moore S 

PROVIDER: S-EPMC3789833 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature