Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose-response meta-analysis.

ABSTRACT:

Background

Epidemiological studies evaluating the association of vitamin B6, vitamin B12 and methionine with breast cancer risk have produced inconsistent results.

Methods

Pertinent studies were identified by a search in PubMed and Web of Knowledge. Random-effect model was used. Dose-response relationship was assessed by restricted cubic spline.

Results

The combined relative risk (95% confidence interval) of breast cancer for the highest vs lowest category of serum pyridoxal 5'-phosphate (PLP, active form of vitamin B6) levels and dietary methionine intake was 0.80 (0.66-0.98, P=0.03) and 0.94 (0.89-0.99, P=0.03), respectively, and the associations of breast cancer with higher serum PLP levels and dietary methionine intake were significant among post-menopausal women,

SUBMITTER: Wu W 

PROVIDER: S-EPMC3790153 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature