Proteomic analysis of gingival tissue and alveolar bone during alveolar bone healing.

ABSTRACT: Bone tissue regeneration is orchestrated by the surrounding supporting tissues and involves the build-up of osteogenic cells, which orchestrate remodeling/healing through the expression of numerous mediators and signaling molecules. Periodontal regeneration models have proven useful for studying the interaction and communication between alveolar bone and supporting soft tissue. We applied a quantitative proteomic approach to analyze and compare proteins with altered expression in gingival soft tissue and alveolar bone following tooth extraction. For target identification and validation, hard and soft tissue were extracted from mini-pigs at the indicated times after tooth extraction. From triplicate experiments, 56 proteins in soft tissue and 27 proteins in alveolar bone were found to be di

SUBMITTER: Yang HY 

PROVIDER: S-EPMC3790282 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature