Lifestyle and metformin treatment favorably influence lipoprotein subfraction distribution in the Diabetes Prevention Program.

ABSTRACT:

Context

Although intensive lifestyle change (ILS) and metformin reduce diabetes incidence in subjects with impaired glucose tolerance (IGT), their effects on lipoprotein subfractions have not been studied.

Objective

The objective of the study was to characterize the effects of ILS and metformin vs placebo interventions on lipoprotein subfractions in the Diabetes Prevention Program.

Design

This was a randomized clinical trial, testing the effects of ILS, metformin, and placebo on diabetes development in subjects with IGT.

Participants

Selected individuals with IGT randomized in the Diabetes Prevention Program participated in the study.

Interventions

Interventions included randomization to metformin 850 mg or placebo twice daily or ILS aimed at a 7% weight

SUBMITTER: Goldberg R 

PROVIDER: S-EPMC3790618 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature