Pancreatic β-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity.

ABSTRACT:

Context

Understanding intersubject variability in glycemic control following exercise training will help individualize treatment.

Objective

Our aim was to determine whether this variability is related to training-induced changes in insulin sensitivity or pancreatic β-cell function.

Design, setting, and participants

We conducted an observational clinical study of 105 subjects with impaired glucose tolerance or type 2 diabetes.

Interventions and main outcome measures

Individual subject changes in fitness (VO2max), glycemia (glycosylated hemoglobin, fasting glucose, oral glucose tolerance test), insulin sensitivity (hyperinsulinemic-euglycemic clamp), oral glucose-stimulated insulin secretion (GSIS), and disposition index (DI) were measured following 12 to 16 week

SUBMITTER: Solomon TP 

PROVIDER: S-EPMC3790622 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature