Spatial analysis of slowly oscillating electric activity in the gut of mice using low impedance arrayed microelectrodes.

ABSTRACT: Smooth and elaborate gut motility is based on cellular cooperation, including smooth muscle, enteric neurons and special interstitial cells acting as pacemaker cells. Therefore, spatial characterization of electric activity in tissues containing these electric excitable cells is required for a precise understanding of gut motility. Furthermore, tools to evaluate spatial electric activity in a small area would be useful for the investigation of model animals. We thus employed a microelectrode array (MEA) system to simultaneously measure a set of 8×8 field potentials in a square area of ∼1 mm(2). The size of each recording electrode was 50×50 µm(2), however the surface area was increased by fixing platinum black particles. The impedance of microelectrode was sufficiently low to apply a high-

SUBMITTER: Taniguchi M 

PROVIDER: S-EPMC3790767 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature