How to use not-always-reliable binding site information in protein-protein docking prediction.

ABSTRACT: In many protein-protein docking algorithms, binding site information is used to help predicting the protein complex structures. Using correct and accurate binding site information can increase protein-protein docking success rate significantly. On the other hand, using wrong binding sites information should lead to a failed prediction, or, at least decrease the success rate. Recently, various successful theoretical methods have been proposed to predict the binding sites of proteins. However, the predicted binding site information is not always reliable, sometimes wrong binding site information could be given. Hence there is a high risk to use the predicted binding site information in current docking algorithms. In this paper, a softly restricting method (SRM) is developed to solve this pro

SUBMITTER: Li L 

PROVIDER: S-EPMC3790831 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature