Delayed dendritic development in newly generated dentate granule cells by cell-autonomous expression of the amyloid precursor protein.

ABSTRACT: Neuronal connectivity and synaptic remodeling are fundamental substrates for higher brain functions. Understanding their dynamics in the mammalian allocortex emerges as a critical step to tackle the cellular basis of cognitive decline that occurs during normal aging and in neurodegenerative disorders. In this work we have designed a novel approach to assess alterations in the dynamics of functional and structural connectivity elicited by chronic cell-autonomous overexpression of the human amyloid precursor protein (hAPP). We have taken advantage of the fact that the hippocampus continuously generates new dentate granule cells (GCs) to probe morphofunctional development of GCs expressing different variants of hAPP in a healthy background. hAPP was expressed together with a fluorescent repor

SUBMITTER: Morgenstern NA 

PROVIDER: S-EPMC3791211 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature