Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia.

ABSTRACT:

Background

Hippocampal atrophy is a well-known feature of Alzheimer's disease (AD), but sensitivity and specificity of hippocampal volumetry are limited. Neuropathological studies have shown that hippocampal subfields are differentially vulnerable to AD; hippocampal subfield volumetry may thus prove to be more accurate than global hippocampal volumetry to detect AD.

Methods

CA1, subiculum and other subfields were manually delineated from 40 healthy controls, 18 AD, 17 amnestic Mild Cognitive Impairment (aMCI), and 8 semantic dementia (SD) patients using a previously developed high resolution MRI procedure. Non-parametric group comparisons and receiver operating characteristic (ROC) analyses were conducted. Complementary analyses were conducted to evaluate differences of hemi

SUBMITTER: La Joie R 

PROVIDER: S-EPMC3791274 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature