Effects of bariatric surgery on human small artery function: evidence for reduction in perivascular adipocyte inflammation, and the restoration of normal anticontractile activity despite persistent obesity.

ABSTRACT:

Objectives

The aim of this study was to investigate the effects of bariatric surgery on small artery function and the mechanisms underlying this.

Background

In lean healthy humans, perivascular adipose tissue (PVAT) exerts an anticontractile effect on adjacent small arteries, but this is lost in obesity-associated conditions such as the metabolic syndrome and type II diabetes where there is evidence of adipocyte inflammation and increased oxidative stress.

Methods

Segments of small subcutaneous artery and perivascular fat were harvested from severely obese individuals before (n = 20) and 6 months after bariatric surgery (n = 15). Small artery contractile function was examined in vitro with wire myography, and perivascular adipose tissue (PVAT) morphology was assessed

SUBMITTER: Aghamohammadzadeh R 

PROVIDER: S-EPMC3791397 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature