Effect of magnetic dipolar interactions on nanoparticle heating efficiency: implications for cancer hyperthermia.

ABSTRACT: Nanostructured magnetic systems have many applications, including potential use in cancer therapy deriving from their ability to heat in alternating magnetic fields. In this work we explore the influence of particle chain formation on the normalized heating properties, or specific loss power (SLP) of both low- (spherical) and high- (parallelepiped) anisotropy ferrite-based magnetic fluids. Analysis of ferromagnetic resonance (FMR) data shows that high particle concentrations correlate with increasing chain length producing decreasing SLP. Monte Carlo simulations corroborate the FMR results. We propose a theoretical model describing dipole interactions valid for the linear response regime to explain the observed trends. This model predicts optimum particle sizes for hyperthermia to about 30

SUBMITTER: Branquinho LC 

PROVIDER: S-EPMC3791447 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature