[Gd(CyPic3A)(H2O)2]-: a stable, bis(aquated) and high-relaxivity Gd(III) complex.

ABSTRACT: We report the synthesis and MR relevant properties of CyPic3A, a heptadentate chelator that forms ternary Gd(III) complexes of hydration state q = 2. [Gd(CyPic3A)(H2O)2](-) affords an r1 value of 5.70 mM(-1) s(-1) at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes.

SUBMITTER: Gale EM 

PROVIDER: S-EPMC3791611 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature