Age-dependent exacerbation of white matter stroke outcomes: a role for oxidative damage and inflammatory mediators.

ABSTRACT:

Background and purpose

Subcortical white matter stroke (WMS) constitutes up to 30% of all stroke subtypes. Mechanisms of oligodendrocyte and axon injury and repair play a central role in the damage and recovery after this type of stroke, and a comprehensive study of these processes requires a specialized experimental model that is different from common large artery, gray matter stroke models. Diminished recovery from stroke in aged patients implies that damage and repair processes are affected by advanced age, but such effects have not been studied in WMS.

Methods

WMS was produced with focal microinjection of the vasoconstrictor N5-(1-iminoethyl)-L-ornithine into the subcortical white matter ventral to the mouse forelimb motor cortex in young adult (2 months), middle-aged (1

SUBMITTER: Rosenzweig S 

PROVIDER: S-EPMC3791618 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature