Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression.

ABSTRACT: Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its progression-free survival. However, current antiangiogenic therapy induces serious adverse effects including neuronal cytotoxicity and tumor invasiveness and resistance to therapy. Although it has been suggested that the physical microenvironment has a key role in tumor angiogenesis and progression, the mechanism by which physical properties of extracellular matrix control tumor angiogenesis and glioblastoma progression is not completely understood. Herein we show that physical compaction (the process in which cells gather and pack together and cause associated changes in cell shape and size) of human glioblastoma cell lines U87MG, U251, and LN229 induces expression of collagen types IV and VI and th

SUBMITTER: Mammoto T 

PROVIDER: S-EPMC3791684 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature