Hierarchical excitatory synaptic connectivity in mouse olfactory cortex.

ABSTRACT: Topological motifs in synaptic connectivity-such as the cortical column-are fundamental to processing of information in cortical structures. However, the mesoscale topology of cortical networks beyond columns remains largely unknown. In the olfactory cortex, which lacks an obvious columnar structure, sensory-evoked patterns of activity have failed to reveal organizational principles of the network and its structure has been considered to be random. We probed the excitatory network in the mouse olfactory cortex using variance analysis of paired whole-cell recording in olfactory cortex slices. On a given trial, triggered network-wide bursts in disinhibited slices had remarkably similar time courses in widely separated and randomly selected cell pairs of pyramidal neurons despite significant

SUBMITTER: McGinley MJ 

PROVIDER: S-EPMC3791725 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature