Ordered kinetochore assembly in the human-pathogenic basidiomycetous yeast Cryptococcus neoformans.

ABSTRACT:

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Kinetochores facilitate interaction between chromosomes and the spindle apparatus. The formation of a metazoan trilayered kinetochore is an ordered event in which inner, middle, and outer layers assemble during disassembly of the nuclear envelope during mitosis. The existence of a similar strong correlation between kinetochore assembly and nuclear envelope breakdown in unicellular eukaryotes is unclear. Studies in the hemiascomycetous budding yeasts Saccharomyces cerevisiae and Candida albicans suggest that an ordered kinetochore assembly may not be evolutionarily conserved. Here, we utilized high-resolution time-lapse microscopy to analyze the localization patterns of a series of putative kinetochore proteins in the basidiomycetous budding yeast Cryptococcus neoformans,

SUBMITTER: Kozubowski L 

PROVIDER: S-EPMC3791896 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature