The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus.

ABSTRACT: Aspergillus fumigatus is the causative agent of invasive aspergillosis, leading to infection-related mortality in immunocompromised patients. We previously showed that the conserved and unique-to-fungi veA gene affects different cell processes such as morphological development, gliotoxin biosynthesis and protease activity, suggesting a global regulatory effect on the genome of this medically relevant fungus. In this study, RNA sequencing analysis revealed that veA controls the expression of hundreds of genes in A. fumigatus, including those comprising more than a dozen known secondary metabolite gene clusters. Chemical analysis confirmed that veA controls the synthesis of other secondary metabolites in this organism in addition to gliotoxin. Among the secondary metabolite gene clusters reg

SUBMITTER: Dhingra S 

PROVIDER: S-EPMC3792039 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature