Different structures involved during ictal and interictal epileptic activity in malformations of cortical development: an EEG-fMRI study.

ABSTRACT: Malformations of cortical development (MCDs) are commonly complicated by intractable focal epilepsy. Epileptogenesis in these disorders is not well understood and may depend on the type of MCD. The cellular mechanisms involved in interictal and ictal events are notably different, and could be influenced independently by the type of pathology. We evaluated the relationship between interictal and ictal zones in eight patients with different types of MCD in order to better understand the generation of these activities: four had nodular heterotopia, two focal cortical dysplasia and two subcortical band heterotopia (double-cortex). We used the non-invasive EEG-fMRI technique to record simultaneously all cerebral structures with a high spatio-temporal resolution. We recorded interictal and ictal

SUBMITTER: Tyvaert L 

PROVIDER: S-EPMC3792088 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature