Pharmacogenetics of leptin in antipsychotic-associated weight gain and obesity-related complications.

ABSTRACT: Second-generation antipsychotics can greatly improve symptoms of psychosis-spectrum disorders. Unfortunately, these drugs are associated with weight gain, which increases a patient's risk for developing chronic diseases including Type 2 diabetes, cardiovascular diseases or other obesity-related complications. There are interindividual differences in weight gain resulting from antipsychotic drug use that may be explained by pharmacodynamic characteristics of these agents as well as clinical factors. In addition, genetic variations in pathways associated with satiety are increasingly recognized as potential contributors to antipsychotic-associated weight gain. Polymorphisms in the leptin gene, as well as the leptin receptor gene, are potential pharmacogenetic markers associated with these ou

SUBMITTER: Lee AK 

PROVIDER: S-EPMC3792568 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature